Study of oral cholesterol-lowering pill in children with HeFH
Part of Heart & circulation, Hormones & metabolism clinical trials.
This study tests an experimental daily pill (enlicitide decanoate) that lowers LDL ('bad') cholesterol in children and teens with a genetic condition called heterozygous familial hypercholesterolemia (HeFH). It aims to see if this medicine can safely help reduce their high cholesterol levels.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your child must have a confirmed diagnosis of heterozygous familial hypercholesterolemia (HeFH), either by a doctor's evaluation or a genetic test.
- Your child's 'bad' cholesterol (LDL-C) level must be 130 mg/dL or higher on a fasting blood test.
- Your child must be on a stable dose of cholesterol-lowering medication(s) for at least 30 days before the trial starts, with no planned changes during the study.
- Your child must be taking an optimized daily dose of statin (maybe with other meds), or if statins are not possible, must have documented intolerance to at least two different statins (or one statin plus a refusal to take statins) and be on other cholesterol-lowering medication.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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