Momelotinib with a hypomethylating agent for certain blood cancers
Treatments studied
Part of Blood & lymphatic, Cancer clinical trials.
This trial tests a combination of two drugs, momelotinib and a hypomethylating agent, for people with certain slow-growing blood cancers. If you have a diagnosis like chronic myelomonocytic leukemia or chronic neutrophilic leukemia and have an enlarged spleen, this study might be exploring a new treatment option for you.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 years or older.
- You must have a diagnosis of a specific type of blood cancer, such as chronic myelomonocytic leukemia or chronic neutrophilic leukemia.
- Your disease must be in a chronic phase, meaning you have less than 10% blasts (immature cells) in your blood or bone marrow.
- You must have an enlarged spleen, either felt as at least 5 cm below your ribs or seen on imaging as at least 450 cm3.
- You should have adequate organ function, including kidneys and liver, as determined by blood tests.
- You must be willing and able to use effective contraception if you or your partner could become pregnant.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
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This study tests a new drug, momelotinib, for people with a low-risk form of myelodysplastic syndrome (MDS) who need red blood cell transfusions and have already tried one other treatment (like ESAs or luspatercept). The goal is to see if momelotinib can help reduce transfusion needs.
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