Permissive lung-protective ventilation for critically ill patients on a breathing machine
Part of Lungs & breathing clinical trials.
This trial tests whether a more lenient approach to lung-protective ventilation can improve outcomes for patients who need a breathing machine (ventilator) in the intensive care unit. It aims to find a balance that is safer for the lungs while still being effective.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are admitted to one of the participating ICUs.
- You are already on a breathing machine (ventilator) and are expected to need it for at least 24 hours.
- You are 18 years or older.
- You have not been on a breathing machine for more than 1 hour in the ICU, or for more than 6 hours just before coming to the ICU (like in the operating room or ER).
- You are not on ECMO (a heart-lung bypass machine).
- You do not have severe chronic lung disease (COPD GOLD stage III or IV).
- You do not have a condition that makes high carbon dioxide levels dangerous, such as recent heart ischemia or increased brain pressure from injury.
- You do not have a nerve or muscle condition that might keep you on the breathing machine longer (like Guillain-Barré syndrome, spinal cord injury, ALS, multiple sclerosis, or myasthenia gravis).
- You are not pregnant (if applicable), not in another similar trial, and are not receiving only comfort care.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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