Guided treatment vs usual care for stubborn depression
Treatments studied
Part of Mental health clinical trials.
This trial tests if using an algorithm to guide treatment works better than standard care for people whose depression hasn't gotten better with previous treatments. It aims to find a more effective approach for those with treatment-resistant depression.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with unipolar depression (not bipolar).
- Your depression has not been in stable remission for at least 12 months.
- You score at least 21 on a depression severity questionnaire (MDI).
- You are between 18 and 64 years old.
- You are currently taking medication for depression.
- You have not changed your depression treatment in the last 4 weeks.
- You are an outpatient (not hospitalized).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a personalized brain stimulation method called neuronavigated aiTBS for people with depression that hasn't improved with at least two prior treatments. The goal is to see if this therapy can safely and effectively reduce depressive symptoms.
This study tests a type of brain stimulation called rTMS that is guided by brain scans to treat depression. It may help people who haven't gotten better with at least two past treatments.
This study uses a blood test (biomarker) to help pick the antidepressant that might work best for you. It compares two treatments—standard antidepressants and ketamine—in people with major depression who haven't gotten enough relief from one prior treatment.
This trial tests two different ways of delivering transcranial magnetic stimulation (TMS) to see which works better for people with depression that hasn't improved with medication.
This trial tests whether a non-invasive ultrasound technique can help people whose depression has not improved with standard treatments. You would receive the ultrasound treatment while having MRI scans to see how your brain changes.
This study helps people with moderate depression decide between medication and therapy. Your doctor will work with you to pick the best option.
Hear when a new Treatment Resistant Depression (TRD) trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.