Dotinurad vs allopurinol for gout with lumps
Treatments studied
Part of Bones, joints & muscles clinical trials.
This trial is testing a new gout medication, dotinurad, compared to the standard treatment allopurinol for people with tophaceous gout (gout that causes hard lumps). It aims to see if dotinurad is better at reducing uric acid and shrinking those lumps.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 75 years old.
- You have had gout for at least 1 year.
- You have at least one noticeable tophus (a hard lump of uric acid) on your hands, wrists, feet, or ankles that is between 5 and 30 millimeters wide.
- Your blood uric acid level is at least 5.0 mg/dL at two separate checkups before the trial starts.
- You are not pregnant or breastfeeding, and you agree to use effective birth control during the study and for 30 days after.
- You do not have a history of kidney stones in the past year, cancer in the last 5 years (except certain skin cancers), or a known allergy to dotinurad, colchicine, or NSAIDs.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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