Testing Dotinurad for Gout in People Who Can't Take Other Medications
Treatments studied
Part of Bones, joints & muscles, Genetic & congenital, Hormones & metabolism clinical trials.
This trial tests a new drug called dotinurad for gout patients whose standard medications either don't work or cause side effects. Dotinurad works differently by helping your body get rid of uric acid (the substance that causes gout attacks), and the study will see if it safely lowers uric acid levels.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with gout for at least 1 year based on clinical criteria
- You cannot tolerate or are allergic to allopurinol or febuxostat, OR previous uricase treatment didn't work well enough
- Your uric acid level is between 6.0 and 10.5 mg/dL at two screening visits, one month apart
- You have not had kidney stones in the past year
- You are willing to use birth control (if able to have children) or abstain from sex during the trial and for 30 days after
- You do not have active cancer, HIV, Hepatitis B, or Hepatitis C
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study compares a new gout medicine called dotinurad to the common medicine allopurinol. It is for people who have had gout for at least a year, have had at least 2 gout attacks in the last year, and are already taking a stable dose of allopurinol but still have high uric acid levels.
This trial tests whether starting dotinurad, a medication that lowers uric acid, at different times after a gout flare begins can help the flare resolve faster. It may help people with frequent or severe gout attacks find quicker relief.
This study compares two different treatment goals for a blood level called urate in people with gout. The goal is to see which approach lowers gout flares better while helping people feel better.
This trial tests an experimental drug, SSS11, to see if it is safe and how it affects uric acid levels in people with gout and high uric acid. You may not take other gout medicines during the study.
This study tests a new medicine, NNC4004-0002, for people who have high uric acid levels but no gout symptoms. The goal is to see if it is safe and how well it works in healthy adults aged 35 to 75.
This study tests a medicine called dotinurad to see if it helps lower high uric acid levels in people who also have high blood pressure. It may be an option if you have not taken uric acid lowering drugs recently or have been off them for over 27 days.
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