Testing Dotinurad for Gout in People Who Can't Take Other Medications
Treatments studied
Part of Bones, joints & muscles, Genetic & congenital, Hormones & metabolism clinical trials.
This trial tests a new drug called dotinurad for gout patients whose standard medications either don't work or cause side effects. Dotinurad works differently by helping your body get rid of uric acid (the substance that causes gout attacks), and the study will see if it safely lowers uric acid levels.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with gout for at least 1 year based on clinical criteria
- You cannot tolerate or are allergic to allopurinol or febuxostat, OR previous uricase treatment didn't work well enough
- Your uric acid level is between 6.0 and 10.5 mg/dL at two screening visits, one month apart
- You have not had kidney stones in the past year
- You are willing to use birth control (if able to have children) or abstain from sex during the trial and for 30 days after
- You do not have active cancer, HIV, Hepatitis B, or Hepatitis C
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study compares a new gout medicine called dotinurad to the common medicine allopurinol. It is for people who have had gout for at least a year, have had at least 2 gout attacks in the last year, and are already taking a stable dose of allopurinol but still have high uric acid levels.
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