New drug vs chemotherapy for EGFR-mutated lung cancer
Treatments studied
Part of Cancer, Lungs & breathing clinical trials.
This trial tests a new drug called izalontamab brengitecan (BMS-986507) against standard chemotherapy (platinum plus pemetrexed) for people with a specific type of lung cancer that has an EGFR mutation and has stopped responding to newer targeted pills.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a type of lung cancer called 'non-squamous non-small cell lung cancer' that cannot be cured with surgery or radiation.
- Your cancer has an EGFR mutation, either an exon 19 deletion or L858R change, confirmed by a test.
- Your cancer has gotten worse after you took a third-generation EGFR inhibitor pill (like osimertinib, furmonertinib, or lazertinib) as your last treatment.
- You are healthy enough to receive a standard chemotherapy combination (platinum-based drug plus pemetrexed).
- Cancer has not spread to the lining of your brain or compressed your spinal cord.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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