Mavacamten for mid-to-apical obstruction in HCM
Treatments studied
Part of Heart & circulation clinical trials.
This trial tests if mavacamten can help people with hypertrophic cardiomyopathy (HCM) who have obstruction in the middle or tip of the heart (not the usual outflow tract). You may join if you have symptoms like chest pain or shortness of breath and a pressure gradient above 30 mmHg in these areas.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with hypertrophic cardiomyopathy, with a thickened heart wall (≥15 mm on an echo or MRI, or ≥13 mm with a known genetic cause).
- You have symptoms like chest pain, shortness of breath, dizziness, or fainting, and are in NYHA class II or III (meaning symptoms with moderate activity).
- You have a pressure gradient over 30 mmHg in the mid-ventricle or apex of the heart at rest or when bearing down (Valsalva).
- You do not have obstruction in the usual outflow tract (gradient must be under 30 mmHg at rest and with Valsalva in that area).
- Your heart pumping strength is normal (LVEF at least 50%).
- You do not have other serious heart problems, uncontrolled high blood pressure, or conditions like Fabry disease or amyloidosis.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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