Cholesterol-lowering drug after stroke from brain artery narrowing
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This clinical trial tests whether a new cholesterol-lowering medicine can reduce the risk of another stroke in people who recently had a stroke or mini-stroke caused by a narrowed artery in the brain. The study compares the new medicine to a placebo (a dummy pill) to see if it helps prevent future problems.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 30 and 80 years old, but if you're under 50 you need extra risk factors like long-standing diabetes, high cholesterol, or smoking.
- You must have had a recent stroke or mini-stroke (called a TIA) within the last week.
- A doctor must confirm that one of the main arteries in your brain is narrowed by more than half (over 50%) and that this narrowing caused your stroke or mini-stroke.
- You cannot have had a bleeding stroke or any bleeding in the brain, and you cannot have certain other causes for your symptoms like heart problems or artery tears.
- You cannot have severe liver or kidney disease, uncontrolled high blood pressure, or be pregnant.
- You should not be planning to have a stent or artery-opening procedure soon.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether a cholesterol-lowering medicine (called a PCSK9 inhibitor) can help people who recently had a stroke caused by a narrowed artery in the brain. The goal is to see if it reduces the risk of another stroke or helps recovery.
This trial tests whether adding a PCSK9 inhibitor to standard statin therapy can help people with narrowing in brain arteries that hasn't caused symptoms yet. The goal is to see if this combination lowers plaque and prevents future strokes.
This trial tests whether quickly starting an aggressive cholesterol-lowering treatment after a stroke improves recovery. It is for people who are about to have a procedure to remove a large blood clot from their brain.
This study tests a medication called alirocumab (given as an injection) to see if it can stabilize the fatty buildup (plaque) in the carotid artery that caused your recent stroke or mini-stroke. It might help reduce the risk of another event.
This trial tests whether giving a cholesterol-lowering injection (called a PCSK9 inhibitor) early after a stroke helps improve recovery and lowers cholesterol. It is for people whose stroke is caused by narrowed arteries, not by heart problems.
This trial tests whether adding an intensive cholesterol-lowering drug (called a PCSK9 inhibitor) to standard care can reduce the risk of another stroke or heart attack in people who recently had a stroke from narrowed brain or neck arteries. It is a high-dose approach designed to rapidly lower cholesterol and may offer extra protection for those with high Lp(a).
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