PCSK9 inhibitor with statin for asymptomatic brain artery narrowing
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial tests whether adding a PCSK9 inhibitor to standard statin therapy can help people with narrowing in brain arteries that hasn't caused symptoms yet. The goal is to see if this combination lowers plaque and prevents future strokes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 80 years old.
- You have a 50% to 99% narrowing in a major brain artery (confirmed by imaging) but have never had a stroke or mini-stroke from it.
- Your LDL (bad) cholesterol is at least 1.8 mmol/L (about 70 mg/dL).
- You have not been treated with a PCSK9 inhibitor before.
- You can have an MRI (no metal implants, claustrophobia, or other MRI safety issues).
- You do not have certain other causes of artery narrowing, like heart problems, bleeding disorders, or severe liver or kidney disease.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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