PCSK9 inhibitor with statin for asymptomatic brain artery narrowing
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial tests whether adding a PCSK9 inhibitor to standard statin therapy can help people with narrowing in brain arteries that hasn't caused symptoms yet. The goal is to see if this combination lowers plaque and prevents future strokes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 80 years old.
- You have a 50% to 99% narrowing in a major brain artery (confirmed by imaging) but have never had a stroke or mini-stroke from it.
- Your LDL (bad) cholesterol is at least 1.8 mmol/L (about 70 mg/dL).
- You have not been treated with a PCSK9 inhibitor before.
- You can have an MRI (no metal implants, claustrophobia, or other MRI safety issues).
- You do not have certain other causes of artery narrowing, like heart problems, bleeding disorders, or severe liver or kidney disease.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether a PCSK9 inhibitor (a drug that lowers cholesterol) can help people who recently had a stroke caused by narrowing of an artery inside the skull. It aims to see if the drug can prevent more strokes and improve recovery.
This study looks at strategies to improve cholesterol treatment in adults whose brain arteries are narrowed and who have had symptoms. Better cholesterol management may help reduce future problems related to this condition.
This trial tests a combination of blood thinners to prevent another stroke in people who have a narrowed artery in the brain. It compares standard treatment to a combination of low-dose blood thinners to see if this approach works better to prevent future strokes.
This trial tests whether placing a stent in a severely narrowed brain artery, along with aggressive medication, can prevent another stroke better than medication alone. It is for people who had a mild stroke within the last 30 days due to a 70-99% blockage in a major brain artery.
This trial is testing an interventional treatment for people who have severe narrowing (70-99%) in a major brain artery that has caused a stroke or mini-stroke in the past year. The goal is to see if this treatment can help prevent future strokes.
This study tests whether starting a cholesterol-lowering drug called a PCSK9 inhibitor soon after a heart attack can help prevent future blockages. If you had a heart attack, received a stent, and have other arteries with minor blockages, this trial may be for you.
Hear when a new Intracranial Atherosclerosis trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.