Stabilising risky neck artery plaque after stroke or mini-stroke
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This study tests a medication called alirocumab (given as an injection) to see if it can stabilize the fatty buildup (plaque) in the carotid artery that caused your recent stroke or mini-stroke. It might help reduce the risk of another event.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 40 and 80 years old
- You had a recent (within 28 days) stroke or mini-stroke affecting the carotid artery (the main artery in your neck that supplies blood to the brain)
- Your carotid artery is moderately narrowed (50-69%) as seen on a CT or angiography scan
- An MRI shows that the fatty plaque in that artery is 'unstable' or 'high-risk'
- You are already on a high-intensity statin (like atorvastatin 40-80 mg or rosuvastatin 20-40 mg) for at least 4 weeks, or you are willing to start atorvastatin 80 mg daily
- Your 'bad' cholesterol (LDL) is at least 70 mg/dL
- You can undergo an MRI scan (no metal implants, claustrophobia, etc.)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a new class of cholesterol-lowering medicine (PCSK9 inhibitor) to see if it can make unstable plaques in the carotid artery more stable, reducing the risk of stroke. If you have carotid narrowing and high LDL despite statins, this might help prevent future problems.
This study compares two approaches for people who have recently had a stroke or mini-stroke caused by a moderately narrowed carotid artery in the neck. Half will get the best medical treatment alone (like clot-preventing medicines and risk-factor management), and the other half will get the same medical treatment plus a procedure to open the narrowed artery (either surgery or a stent). The goal is to see which approach better prevents future strokes.
This clinical trial tests whether a new cholesterol-lowering medicine can reduce the risk of another stroke in people who recently had a stroke or mini-stroke caused by a narrowed artery in the brain. The study compares the new medicine to a placebo (a dummy pill) to see if it helps prevent future problems.
This trial tests whether a higher-dose statin can help after an ischemic stroke in people who have specific plaque patterns in brain blood vessels. It may help lower the risk of another stroke by targeting the artery plaque process.
This trial tests whether adding a PCSK9 inhibitor to a statin is better than a statin alone for people with mild-to-moderate narrowing of the carotid artery (the main artery in the neck). It looks at how well these treatments slow plaque buildup and prevent strokes.
This trial tests if adding folic acid to a statin can help stabilize plaques in the carotid artery (neck artery) to prevent stroke. You may qualify if you have carotid plaque and are not already on certain supplements.
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