Study on causes of enlarged head with possible tumor risk
Part of Bones, joints & muscles, Brain & nervous system, Cancer, Genetic & congenital clinical trials.
This study looks for genetic causes in children who have a very large head (megalencephaly) confirmed by brain MRI, which may also carry a risk for certain tumors. It aims to identify the underlying genetic reason using whole genome sequencing.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Child must have a head size at least 3 standard deviations above average, confirmed by brain MRI showing megalencephaly.
- Child may also have a neurodevelopmental disorder, but it is not required.
- Parents or guardians must agree to participate and not object to testing.
- Child must be covered by a social security health plan.
- Child must not have already received a genetic diagnosis for the enlarged head or had previous genetic testing for this condition.
- Child must not have had standard genetic testing (like whole genome sequencing) already.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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