Genetic causes of enlarged brain with tumor risk
Part of Bones, joints & muscles, Brain & nervous system, Cancer, Genetic & congenital clinical trials.
This trial studies children with very large heads (caused by an enlarged brain) to understand the genetic reasons behind it. It looks for genes that might also increase the risk of tumors, using a full read of the DNA (whole genome sequencing).
Summary written for real people, not researchers, by Clin2.
Who can take part
- Large head size (at least 3 standard deviations above average) confirmed by brain MRI as megalencephaly
- Ready to have genetic testing (whole genome sequencing) to look for causes
- Parents or guardians must agree to participate
- Must be covered by a social security plan
- No previous genetic testing for this condition and no known genetic diagnosis yet
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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