Tegavivint and gemcitabine for relapsed osteosarcoma
Treatments studied
Part of Cancer clinical trials.
This trial tests a new drug called tegavivint combined with the chemotherapy drug gemcitabine for people whose osteosarcoma has come back or stopped responding to treatment. The goal is to see if this combination can help shrink or control the cancer.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have osteosarcoma that has come back or not responded to treatment, and you must have received at least 3 of these drugs before: methotrexate, doxorubicin, cisplatin, or ifosfamide.
- You need to be at least 60 on a scale that measures your ability to do daily activities (like being up and about, even if in a wheelchair).
- You must have recovered from the side effects of any prior cancer treatments, with specific time gaps since your last treatment (for example, at least 2 weeks since chemotherapy, 7 days since certain targeted drugs, etc.).
- Your blood counts, kidney function, liver function, and heart function need to be within acceptable levels (tests will be done to check).
- You cannot have active, uncontrolled infections, certain bone metabolism disorders, or a history of organ or stem cell transplant.
- You must be willing to avoid certain medications (like strong CYP3A4 drugs, bisphosphonates, and denosumab) and use effective birth control if you are of childbearing age.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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