Clin2
NCT07146048Possibly a fitRecruiting

Stopping penicillin for early rheumatic heart disease

Rheumatic Heart Disease

Part of Heart & circulation, Infections clinical trials.

This trial tests whether it is safe to stop taking daily penicillin for children and teens whose rheumatic heart disease has improved or stayed mild. If you took part in the GOALIE study and your heart condition is now stable, this study may help determine if you can safely stop medication.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 3
Enrollment
922 people
Ages
5 years to 20 years
Study type
Interventional

Who can take part

  • You took part in the earlier GOALIE study
  • Your last heart ultrasound showed normal or only mild rheumatic heart disease
  • You are between 5 and 20 years old
  • You do not have severe rheumatic heart disease
  • You have not moved far away from the study center
  • You do not have a known penicillin allergy

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07830108Not yet recruiting· Phase 3
Treatments for acute rheumatic fever and heart inflammation

This trial tests different treatments for acute rheumatic fever with heart inflammation (carditis) to see if they can reduce damage to the heart valves after 6 months. It aims to find better ways to prevent long-term rheumatic heart disease.

Darwin, Northern Territory
NCT07078357Not yet recruiting· Phase 1/Phase 2
Testing a new strep vaccine for safety and immune response

This study tests a new vaccine called StreptInCor that may help prevent rheumatic fever (a condition caused by strep infections that can damage the heart). It is an early trial to check if the vaccine is safe and produces a good immune response in healthy adults.

São Paulo, São Paulo
NCT07065474Not yet recruiting
Learning about heart health through fun activities for school students

This study uses fun, educational activities to help school children learn about rheumatic fever and rheumatic heart disease, which affect the heart after untreated throat infections. It will see if these activities improve students' knowledge and awareness.

Kathmandu, Bagmati
NCT07798232Not yet recruiting· Phase 3
Penicillin to prevent rheumatic heart disease in children

This study tests whether giving penicillin to healthy school-aged children for a few years can prevent rheumatic heart disease, a serious heart condition that can start after a strep throat infection. If your child qualifies, they would receive free heart checks and treatment that could keep their heart healthy.

Kampala, Uganda
NCT07790302Not yet recruiting
Early rheumatic heart disease screening study in children across Africa

This study checks children aged 5–8 for early signs of rheumatic heart disease, a heart problem that can follow a strep throat infection. It aims to see how common it is in different parts of Africa to help prepare for a future vaccine. Children with a normal heart ultrasound at the start may join.

Kampala, Uganda
NCT07625228Not yet recruiting
Azithromycin for preventing heart damage in rheumatic heart disease

This study tests whether the antibiotic azithromycin can help prevent further heart damage in young people with mild or moderate rheumatic heart disease (a condition caused by rheumatic fever that affects the heart valves). Participants will receive study medication and regular check-ups to see if it helps keep their heart healthy.

Hear when a new Rheumatic Heart Disease trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.