Laser vs estrogen cream for vaginal dryness in Sjögren's
Part of Bones, joints & muscles, Eyes & vision, Immune system & allergy, Mouth & dental, Skin clinical trials.
This trial compares two treatments for vaginal dryness in women with Sjögren's disease: a CO2 laser procedure versus a topical estrogen cream called promestriene. The goal is to see which option works better to relieve dryness and discomfort.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with Sjögren's disease.
- Your Sjögren's symptoms are stable and mild (low disease activity).
- You are not taking steroids or only take a low dose (15 mg prednisone or less per day).
- You are currently experiencing vaginal dryness.
- You do not have a history of breast, uterine, or ovarian cancer, blood clots, or serious heart, kidney, or liver problems.
- You do not have another autoimmune disease like lupus, rheumatoid arthritis, or scleroderma.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if combining a special laser treatment with a vaginal estrogen cream can help relieve menopause symptoms like vaginal dryness, burning, and pain during sex. It may be a good option for women who have not used hormone therapy recently.
This study compares two types of laser treatments to improve vaginal discomfort (GSM) in people who had breast cancer and are now dealing with menopause-related symptoms. If you qualify, you may be assigned to one of the laser types to see which works better and is easier to tolerate.
This study tests if a fractional CO2 laser can safely improve vaginal atrophy symptoms like dryness, irritation, or pain during sex in postmenopausal women. It offers a non-hormonal option for those who haven't used hormone therapy or vaginal products recently.
This trial tests a combination of a vaginal laser and a special moisturizing gel to help with vaginal dryness and discomfort in people who have had cancer but cannot use estrogen treatments.
This study tests whether a combination of laser treatment and a topical treatment can improve vaginal discomfort and dryness in people with breast cancer who take hormone therapy. It aims to see if symptoms and quality of life improve when the condition affects vaginal health exams.
This study tests an investigational drug called RSLV-132 in women with Sjögren's disease to see if it can reduce symptoms like fatigue and dryness. You may join if you've been diagnosed in the last 30 years and have persistent symptoms.
Hear when a new Sjogren Syndrome trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.