Vaccine to prevent cancer in people with Lynch syndrome
Part of Cancer, Digestive system, Genetic & congenital, Hormones & metabolism clinical trials.
This trial tests a personalized vaccine made from your own immune cells to try to prevent Lynch syndrome-related cancers. It is for people with Lynch syndrome who have not had most of their colon removed and meet certain health criteria.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have a confirmed Lynch syndrome gene change (in MLH1, MSH2, or MSH6) – without a prior Lynch-related cancer if you have MLH1 or MSH2; if you have MSH6 you may be included even if you had a prior Lynch-related cancer, as long as you have been cancer-free for over a year.
- You must not have had surgery that removed most or all of your colon (subtotal or total colectomy) because the risk of colon cancer is already very low.
- You must be between 35 and 75 years old (if you have MLH1 or MSH2) or between 40 and 75 (if you have MSH6).
- You must have the HLA-A02:01 tissue type (a blood test can check this).
- You must be in good general health (able to do normal activities), with acceptable blood test results and no major immune or bleeding problems.
- You must have had a recent colonoscopy (within 16 weeks before starting) that shows no cancer or pre-cancer spots, and you must not be taking immune-suppressing drugs by mouth or IV.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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