Predicting muscle relaxant dose for faster paralysis during surgery
Part of Brain & nervous system clinical trials.
This study is testing a new way to predict how quickly a muscle relaxant (rocuronium) works during surgery. The aim is to give each patient the right dose for their body, which may help anaesthesia start more smoothly and safely.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are having surgery that is expected to take longer than 1.5 hours.
- The surgery uses an arterial line (a small tube to monitor your blood pressure constantly).
- You are having general anaesthesia and will receive rocuronium (a muscle relaxant) and propofol (a sleep medicine) as part of the anaesthesia.
- You do not have certain conditions that might affect your muscles, kidneys, liver, or heart rhythm.
- You are not pregnant or breastfeeding, and you can consent for yourself without an interpreter.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study compares a new muscle relaxant medication with a standard one to see how well they work for placing a breathing tube and maintaining muscle relaxation during surgery. It aims to find a safer or more effective option for patients undergoing general anesthesia.
This study compares two ways to monitor muscle relaxation during surgery. It looks at how well a nerve monitor on the arm works versus one on the wrist, to help doctors give the right amount of muscle relaxant medicine.
This trial compares two muscle relaxants, rocuronium and cisatracurium, to see which causes fewer complications in people with chronic kidney disease (not on dialysis) who need general anesthesia. If you have kidney disease and are having surgery that requires a breathing tube, this study may help determine the safer drug for you.
This study tests a new drug called amogammadex sodium to see if it can quickly reverse the effects of muscle relaxants used during surgery. It may help patients wake up and breathe normally sooner after anesthesia.
This trial tests whether a medication that relaxes muscles (called a neuromuscular blocker) improves breathing help during surgery when a type of airway tube is used. It aims to see if it helps patients breathe better while under anesthesia.
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