Internal radiation before prostate surgery for high-risk cancer
Part of Cancer, Kidney & urinary clinical trials.
This trial tests a treatment approach for newly diagnosed, high-risk prostate cancer. You would receive a short course of internal radiation (high-dose-rate brachytherapy) before surgery to remove your prostate. The goal is to see if this combination is safe and works better than surgery alone.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have a new diagnosis of prostate cancer confirmed by biopsy.
- Your cancer must be high-risk, which means you have at least one of these: PSA of 20 or more, aggressive cancer (Gleason 8 or higher), or the cancer has spread outside the prostate (stage T3a or higher).
- Imaging scans (bone scan, CT, or PSMA-PET) must show the cancer has not spread to bones or lymph nodes.
- You have not had hormone therapy (androgen deprivation therapy) for prostate cancer in the last 6 months.
- You are 40 or older and healthy enough to undergo surgery and a type of internal radiation called brachytherapy (as determined by your doctor).
- You have no other cancer in the past 3 years (except some skin cancers or very early bladder/neck cancers).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial studies how safe and effective different high-dose radiation levels are for prostate cancer placed directly in the prostate (HDR brachytherapy). It may help by finding a dose that controls the cancer while keeping side effects acceptable.
This trial tests proton radiation therapy for people with high-risk prostate cancer. It may help by delivering radiation in a more targeted way, with the goal of controlling the cancer while reducing exposure to nearby healthy tissue.
This trial tests a high-dose radiation treatment (brachytherapy) that places tiny radioactive seeds directly into the area where your prostate was. It is for men whose prostate cancer has returned only in that area after having their prostate removed.
This trial tests a focused form of radiation placed inside the prostate to treat only the cancer area in people with low-risk prostate cancer. It aims to control the cancer while limiting treatment to a smaller area.
This study tests a stronger, focused radiation plan for intermediate to higher-risk prostate cancer. It combines a high-dose internal radiation “boost” with external radiation to try to improve cancer control while keeping side effects manageable.
This trial studies a targeted, high-intensity radiation approach given after prostate removal surgery when prostate cancer seems to be coming back locally. It may help control the disease in the pelvis while avoiding treatment that could cause more side effects.
Hear when a new Prostate Cancer (Adenocarcinoma) trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.