Low-dose LSD for premenstrual mood and physical symptoms
Treatments studied
Part of Mental health, Women’s health & pregnancy clinical trials.
This study tests whether taking a very small dose (microdose) of LSD twice a week helps reduce the mood and physical symptoms of PMDD and severe PMS. You would take the study drug or a placebo during the luteal phase (the week before your period) to see if it improves how you feel.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 18 and 45 years old and have regular menstrual cycles (usually 21 to 35 days).
- You must have PMDD or severe PMS, confirmed by mood and physical symptoms that show up in the week before your period and go away after it starts.
- You must not be currently taking medicine or using hormonal birth control for your PMS/PMDD (if using oral contraceptives, you must have stopped at least 6 months ago).
- You must not have had any serious mental health conditions like bipolar disorder, schizophrenia, or severe depression with hallucinations, and no family history of schizophrenia.
- You must be willing to avoid driving or heavy machinery on days you take the study drug, and limit alcohol, cigarettes, and any other substances.
- You must be able to speak and understand German well enough to follow study instructions.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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