Clin2
NCT07686718Possibly a fitRecruiting

Hormone patterns in PMDD vs. healthy controls

Premenstrual Dysphoric Disorder ( PMDD)

Part of Mental health clinical trials.

This study compares hormone levels during the luteal phase (the time between ovulation and your period) in people with PMDD versus those without symptoms. It involves collecting a blood sample mid-luteal phase to better understand what causes PMDD.

Summary written for real people, not researchers, by Clin2.

Phase
N/A
Enrollment
50 people
Ages
18 years to 45 years
Study type
Observational

Who can take part

  • Between 18 and 45 years old
  • Regular periods (cycle length 21–35 days for the last 3 months)
  • Willing to use home ovulation test strips and come to Lancaster for one blood test
  • Able to read and understand English without help
  • Either have a prior PMDD diagnosis from a doctor, or have no history of significant premenstrual mood symptoms
  • Not using hormonal birth control, hormone therapy, or certain antidepressants in the last 3 months

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07771426Not yet recruiting
Comparing people with premenstrual dysphoric disorder to healthy volunteers

This study looks at premenstrual dysphoric disorder (PMDD) and compares people who have it to healthy controls. It may help researchers understand the condition better and could lead to improved treatments.

London, 'London
NCT06771583Recruiting
Finding biomarkers for PMDD in blood samples

This study looks for chemical markers in the blood that might help diagnose PMDD. It involves blood draws and questionnaires over one or two menstrual cycles to see how your body responds to natural hormone changes.

Baltimore, Maryland
NCT07818720Not yet recruiting· Phase 1
Study of an experimental drug for severe PMS (PMDD)

This study tests an experimental medicine for premenstrual dysphoric disorder (PMDD), a severe form of PMS. It is a phase 1 trial, so the main goal is to check the drug's safety and how your body handles it, but it may also help assess its effectiveness.

NCT06704594Recruiting· Phase 4
Study of allopregnanolone for PMDD in women on SSRIs

This trial studies a natural brain chemical called allopregnanolone in women with premenstrual dysphoric disorder (PMDD) that responds to SSRI antidepressants. It aims to understand how the brain adapts and whether this treatment could help.

Baltimore, Maryland
NCT06610305Recruiting· Phase 4
Hormones, mood, and reward in women with PMS-related depression

This study looks at how changes in hormone levels during the menstrual cycle affect mood and the brain's reward system in women with depression that gets worse before their period. The goal is to understand why this happens so better treatments can be developed.

Chapel Hill, North Carolina
NCT07189299Not yet recruiting
Low-dose LSD for premenstrual mood and physical symptoms

This study tests whether taking a very small dose (microdose) of LSD twice a week helps reduce the mood and physical symptoms of PMDD and severe PMS. You would take the study drug or a placebo during the luteal phase (the week before your period) to see if it improves how you feel.

Basel, Canton of Basel-City

Hear when a new Premenstrual Dysphoric Disorder (PMDD) trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.