Mitral valve repair for leaky valve from heart failure
Treatments studied
Part of Heart & circulation clinical trials.
This trial tests a procedure to fix a leaky mitral valve that occurs because the heart muscle is weak or enlarged, and which gets worse with activity. The procedure aims to reduce the leak and improve symptoms and quality of life in people with heart failure.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a type of mitral valve leak (called functional mitral regurgitation) that gets worse when your heart works harder, like when you squeeze a ball or exercise.
- You are already taking the best medicines for heart failure, and your dose has been stable for at least 2 weeks.
- You have symptoms of heart failure (like shortness of breath or fatigue) even with treatment, and you are in class II, III, or IV (meaning you are limited in daily activities).
- In the last year, you have been in the hospital for heart failure, OR a blood test shows a high level of BNP or NT-proBNP.
- Your heart's pumping ability (LVEF) is at least 20%.
- You are able to walk for 6 minutes, and your only limitation is your heart and lung fitness.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether repairing a leaky heart valve (mitral valve) can help people with heart failure feel better and live longer, even when standard heart failure medicines are not working well. The repair is done through a small tube in a blood vessel, avoiding open-heart surgery.
This trial tests a procedure to fix a leaky mitral valve that only becomes severe during exercise. It may help people with symptoms like shortness of breath or fatigue who haven't responded to standard heart medications.
This trial tests a new device designed to fix a leaky mitral valve in people with heart failure. It may help you breathe easier and feel less tired if your valve leak is severe and medicines have not been enough.
This trial tests a clip-based procedure (TEER) to fix a severe leak in the mitral valve for people who have symptoms or heart changes but are at low to medium risk for surgery. The goal is to see if this less invasive option works well and is safe.
This study tests a minimally invasive procedure (edge-to-edge repair) for people whose mitral valve leaks because of an enlarged upper heart chamber (atrial functional mitral regurgitation). The goal is to see if this clip repair improves symptoms and outcomes compared with standard medical therapy alone.
This trial is testing a new device to help people with severe mitral regurgitation (a leaky heart valve) who cannot have open-heart surgery or a valve clip. The device is placed using a thin tube through a blood vessel, and aims to improve symptoms and quality of life.
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