Mitral valve repair for heart failure with atrial leak
Part of Heart & circulation clinical trials.
This study tests a minimally invasive procedure (edge-to-edge repair) for people whose mitral valve leaks because of an enlarged upper heart chamber (atrial functional mitral regurgitation). The goal is to see if this clip repair improves symptoms and outcomes compared with standard medical therapy alone.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Age 18 or older
- Symptoms of heart failure (shortness of breath or fatigue, NYHA class II–IV)
- A mitral leak graded as moderate-to-severe or severe (3+ or 4+) due to an enlarged upper chamber, not from a structural problem with the valve leaflets
- A hospitalization for heart failure in the past year or elevated BNP/NT-proBNP blood levels
- On maximally tolerated heart failure medications for at least 3 months
- Considered high risk or not suitable for open-heart surgery by the study heart team
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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