Heart valve repair to improve heart failure treatment
Part of Heart & circulation clinical trials.
This trial tests whether repairing a leaky heart valve (mitral valve) can help people with heart failure feel better and live longer, even when standard heart failure medicines are not working well. The repair is done through a small tube in a blood vessel, avoiding open-heart surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have heart failure with a weakened heart muscle (ejection fraction 40% or less).
- Your mitral valve leaks significantly, causing blood to flow backward in the heart.
- Your current heart failure medications are not at full doses because of side effects like low blood pressure, kidney problems, or high potassium.
- You still have symptoms like shortness of breath or fatigue (NYHA class II-IVa).
- You have been in the hospital for heart failure in the last year or have a high level of a heart stress marker (NT-proBNP).
- Your doctor thinks the valve can be repaired with a catheter-based procedure.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests a procedure to fix a leaky mitral valve that occurs because the heart muscle is weak or enlarged, and which gets worse with activity. The procedure aims to reduce the leak and improve symptoms and quality of life in people with heart failure.
This trial tests a procedure to fix a leaky mitral valve that only becomes severe during exercise. It may help people with symptoms like shortness of breath or fatigue who haven't responded to standard heart medications.
This trial tests a new device designed to fix a leaky mitral valve in people with heart failure. It may help you breathe easier and feel less tired if your valve leak is severe and medicines have not been enough.
This study tests a minimally invasive procedure (edge-to-edge repair) for people whose mitral valve leaks because of an enlarged upper heart chamber (atrial functional mitral regurgitation). The goal is to see if this clip repair improves symptoms and outcomes compared with standard medical therapy alone.
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