Medicine plus simple polyp removal versus extended sinus surgery
Treatments studied
This study compares two ways to treat chronic sinusitis with nasal polyps: giving a medicine that targets a specific type of inflammation (anti-IL-5 therapy) along with simple removal of polyps, versus a more extensive sinus surgery. The goal is to see which approach better controls your symptoms and reduces the need for repeat treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have nasal polyps seen on a scope in both nostrils, with a certain size (score of 4 or more overall).
- You have had a blocked nose for over 3 months and/or a reduced sense of smell that bothers you.
- You have signs of type 2 inflammation — this is usually checked with a small sample of polyp tissue or a blood test.
- You have already tried standard medical treatment for at least 4 weeks (including steroid nasal sprays) and it didn’t work well enough.
- You have not had sinus surgery for this condition before.
- You do not have certain other conditions like cystic fibrosis, and you are not pregnant or planning pregnancy.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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