Zynrelef vs. nerve block for knee replacement pain
Treatments studied
Part of Bones, joints & muscles clinical trials.
This trial compares a new long-acting painkiller (Zynrelef) to a standard nerve block for pain after knee replacement surgery. It aims to find which method provides better pain relief with fewer side effects.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older
- You are having a first-time total knee replacement on one knee
- You are not pregnant, a prisoner, or unable to consent
- You have not used certain pain medicines recently (see details below)
- You have not had allergic reactions to numbing medicines or NSAIDs (like ibuprofen)
- You do not have a history of asthma or hives from aspirin or NSAIDs
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests two different drugs (dexamethasone and dexmedetomidine) added to a standard nerve block for knee replacement. It aims to see which one provides better pain control after surgery.
This study compares two types of numbing injections (nerve blocks) to see which provides better pain relief after total knee replacement surgery. If you are 65 or older and having your first knee replacement, you may be able to join.
This study compares two types of pain relief for people having knee replacement surgery: a newer long-acting medication called Zynrelef versus the usual injections given around the knee. The goal is to find out which works better for controlling pain after surgery.
This study compares two ways to manage pain after shoulder replacement surgery: a long-acting numbing medicine (ZYNRELEF) versus a temporary nerve block catheter. It aims to see which provides better pain control and recovery.
This trial tests two different numbing medicines for knee replacement surgery. It compares a long-acting numbing medicine (liposomal bupivacaine) with a standard one (ropivacaine) mixed with other drugs to see which provides better pain control. The goal is to find a way to reduce pain and improve recovery.
This trial tests whether a nerve block injected near the knee (with a long-acting pain medicine) works better for controlling pain after a scheduled knee replacement. It may help reduce pain and the need for stronger pain medicines after surgery.
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