Comparing two pain-relief options for knee replacement surgery
Treatments studied
Part of Bones, joints & muscles clinical trials.
This study compares two ways to manage pain after knee replacement surgery: a special pain-relief injection called Zynrelef versus a nerve block (adductor canal block). The goal is to find which method provides better pain control and helps you recover with fewer opioids.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be at least 18 years old.
- You must be scheduled for a total knee replacement on one side (not both).
- You must be able to understand and sign a consent form.
- You cannot be pregnant, a prisoner, or unable to give consent.
- You must not have taken long-acting opioids within 3 days, short-acting opioids within 24 hours, or the local anesthetic bupivacaine within 5 days before surgery.
- You must not have a history of chronic opioid use (daily use for 7+ days in the last 6 months), or have an allergy to NSAIDs or amide-type local anesthetics.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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