Pain Relief Method Comparison for Knee Replacement Surgery
Treatments studied
Part of Bones, joints & muscles, Pain clinical trials.
This study tests a new way to deliver pain medication during and after knee replacement surgery. Researchers compare injecting a long-acting numbing medicine (EXPAREL) directly into the knee joint versus spreading it through the surgical area, to see which method works better for pain control.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Scheduled for total knee replacement surgery for osteoarthritis (bone-on-bone wear in the knee)
- Between 18 and 75 years old with a BMI between 18 and 40 (healthy weight range)
- Able to attend study visits and complete pain assessments after surgery
- No severe allergies to numbing medications, pain relievers, or NSAIDs (like ibuprofen)
- No current substance abuse, marijuana use in past 30 days, or regular opioid pain medication use
- Not pregnant, nursing, or planning pregnancy during the study
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests if a long-lasting numbing medicine called Exparel, given by the surgeon during knee replacement, helps control pain after surgery. It is for people having their first total knee replacement on one knee due to arthritis.
This study compares two ways to manage pain after knee replacement surgery: local numbing medicine injected into the knee versus numbing several nerves in the leg. The goal is to find which method provides better pain control and recovery.
This trial tests two types of numbing injections (nerve blocks) around the knee to help manage pain after total knee replacement surgery. The goal is to see if these injections reduce pain and improve recovery compared to standard pain treatment.
This study compares two different nerve-blocking anesthesia techniques to see which one controls pain better after knee replacement surgery. Both methods are designed to numb the area around your knee so you need less pain medication afterward.
This Phase 2 study compares two ways to reduce pain after total knee replacement (TKA): a steroid-enhanced nerve block versus a numbing shot called Exparel. It aims to see which option improves comfort and recovery after surgery done with spinal anesthesia.
This study compares two ways to manage pain after a total knee replacement: a nerve block (iPACK) versus injecting pain medicine around the knee. The goal is to find which method provides better pain relief with fewer side effects.
Hear when a new Total Knee Arthroplasty trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.