Pain Relief Method Comparison for Knee Replacement Surgery
Treatments studied
Part of Bones, joints & muscles, Pain clinical trials.
This study tests a new way to deliver pain medication during and after knee replacement surgery. Researchers compare injecting a long-acting numbing medicine (EXPAREL) directly into the knee joint versus spreading it through the surgical area, to see which method works better for pain control.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Scheduled for total knee replacement surgery for osteoarthritis (bone-on-bone wear in the knee)
- Between 18 and 75 years old with a BMI between 18 and 40 (healthy weight range)
- Able to attend study visits and complete pain assessments after surgery
- No severe allergies to numbing medications, pain relievers, or NSAIDs (like ibuprofen)
- No current substance abuse, marijuana use in past 30 days, or regular opioid pain medication use
- Not pregnant, nursing, or planning pregnancy during the study
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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