Nerve blocks with dexamethasone and dexmedetomidine for knee replacement
Treatments studied
Part of Bones, joints & muscles clinical trials.
This trial is testing whether adding two medicines (dexamethasone and dexmedetomidine) to the numbing shots (nerve blocks) used during knee replacement surgery can improve pain control and recovery. The study is for people aged 60 to 100 who are having a knee replacement under spinal anesthesia.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 60 and 100 years old
- You are scheduled for a first-time elective knee replacement surgery on one knee
- You are healthy enough for spinal anesthesia and the numbing shots used in this study
- You are not allergic to any of the study medicines (ropivacaine, dexamethasone, dexmedetomidine)
- You do not have a bleeding disorder or take blood thinner that would make nerve blocks unsafe
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests two different drugs (dexamethasone and dexmedetomidine) added to a standard nerve block for knee replacement. It aims to see which one provides better pain control after surgery.
This trial tests a combination of two pain-relief methods after total knee replacement: a spinal injection and a nerve block in the thigh. It aims to provide better pain control during and after surgery.
This trial tests whether adding a sedative medicine (dexmedetomidine) to the standard numbing injection around the knee can improve pain control after total knee replacement. It might help you have less pain and need fewer opioids.
This trial tests whether adding a medication called dexmedetomidine to your anesthesia during hip replacement surgery helps reduce stress on the body and improves your recovery. If you are having a hip replacement and are generally healthy, you may be able to participate.
This trial studies whether giving dexmedetomidine (a sedative) through different routes can make spinal anesthesia last longer during hip or knee replacement surgery. It may help you stay comfortable after surgery with fewer additional pain medicines.
This Phase 2 study compares two ways of reducing nerve pain after knee replacement surgery (total knee arthroplasty). It looks at whether steroid-enhanced pain medicine works better than a different numbing injection to improve recovery and comfort.
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