Knee replacement pain relief with extra nerve blocks and medicines
Treatments studied
Part of Bones, joints & muscles clinical trials.
This study tests whether adding two types of nerve blocks plus two medicines can improve pain relief and recovery after knee replacement surgery. It may help patients have less pain and need fewer opioids.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 60 and 100 years old.
- You are scheduled for a first-time total knee replacement on one knee.
- You are generally healthy or have well-managed medical conditions (ASA I-III).
- You are able to understand the study and give written consent.
- You are eligible for spinal anesthesia and ultrasound-guided nerve blocks.
- You have no allergies to the study medicines (ropivacaine, dexamethasone, dexmedetomidine).
- You do not have bleeding disorders or take blood thinners that prevent safe blocks.
- You do not have severe nerve problems, serious heart/liver/kidney disease, or uncontrolled diabetes.
- You have not used opioids for more than 3 months before surgery.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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