Gene therapy for BAG3-related heart failure
Part of Genetic & congenital, Heart & circulation clinical trials.
This study tests an experimental gene therapy called ALXN2350 for people with dilated cardiomyopathy caused by a specific genetic change in the BAG3 gene. It aims to see if the therapy can improve heart function and slow disease progression.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a confirmed change (mutation) in the BAG3 gene that is known to cause heart muscle disease.
- You have been diagnosed with dilated cardiomyopathy (a condition where the heart is enlarged and struggles to pump blood).
- You have had chronic heart failure for at least 3 months.
- Your heart's pumping strength (ejection fraction) is between 15% and 45%, measured by an echocardiogram (ultrasound of the heart).
- You are taking a stable combination of heart failure medications.
- You have not had any untreated serious heart valve problems.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests a gene therapy (AFTX-201) for people with dilated cardiomyopathy caused by a BAG3 gene mutation. The therapy aims to improve heart function, and the study will check if it is safe and effective.
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This trial tests if danicamtiv can improve heart function in people with dilated cardiomyopathy caused by certain genetic changes. It may help those who have stable symptoms but still need more treatment options.
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This study follows adults with a specific genetic mutation (BAG3) that causes heart muscle weakness. Researchers will track how the disease develops over time to better understand it and help improve future treatments.
This study follows people with a specific genetic change in the BAG3 gene that causes dilated cardiomyopathy (DCM), a condition where the heart muscle is weakened. It aims to understand the natural course of the disease over time.
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