Gene therapy for chronic chest pain
Part of Heart & circulation, Pain clinical trials.
This trial tests a new gene therapy (XC001) delivered through a thin tube into your heart's blood vessels. It aims to grow new blood vessels to relieve chest pain in people with chronic angina who have no other treatment options.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 18 and 85 years old.
- You have chest pain (angina) that doesn't improve with medication and you can't have stents or bypass surgery.
- You have had a stress test or heart imaging showing that part of your heart has reversible low blood flow.
- You have not had a heart attack or stroke in the last 60 days.
- Your heart function is not severely weak (ejection fraction above 25%) and you don't have severe heart failure.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This Phase 2 trial tests whether stem cells placed into the heart artery can safely reduce symptoms in people with “refractory” angina (chest pain) despite maximum heart-healthy medication. You may qualify if your chest pain is limiting your activity and other heart procedures (stents/bypass) aren’t possible or are too risky.
This trial tests whether a small pressure-reducing device placed in a heart vein (the coronary sinus) can reduce symptoms in people with ongoing chest pain from tiny blood vessel problems. It is for angina that has not improved despite standard heart medicines, and only if special heart tests show reversible reduced blood flow.
This trial tests a device called the Neovasc Coronary Sinus Reducer to help people with long-lasting, hard-to-control chest pain (angina) who cannot have artery-opening procedures. It may improve symptoms by changing blood flow in the heart’s vein system.
This trial tests a new stem cell treatment (HeXell-2020) for people with stable coronary artery disease. It aims to see if it's safe and can improve heart function. You may be eligible if you have stable angina and are on regular heart medications.
This trial tests a small device called a coronary sinus reducer that is placed in a vein of the heart to improve blood flow and reduce chest pain in people who still have angina despite medications and cannot have stents or bypass surgery. The procedure is done through a small tube in the groin or arm.
This trial tests whether implanting a small device in the heart’s coronary sinus can reduce symptoms in people with long-lasting “refractory” angina despite taking the usual heart medicines. It may help improve how much activity you can do and reduce angina-related limitations.
Hear when a new Refractory Angina trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.