Levetiracetam to prevent seizures in adults with Down syndrome and Alzheimer's
Treatments studied
Part of Brain & nervous system, Genetic & congenital, Mental health clinical trials.
This trial tests if levetiracetam, a seizure medication, can prevent seizures in adults with Down syndrome who also have Alzheimer's disease. It aims to help manage a common complication and improve quality of life.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have Down syndrome (diagnosed or with typical features).
- You are 40 years or older.
- You have been diagnosed with Alzheimer's dementia based on changes in daily function and thinking tests.
- You have a caregiver who is willing and able to help you daily and attend clinic visits twice a year.
- You are not currently taking any antiepileptic drugs, benzodiazepines, or narcotics.
- You have never had an epileptic seizure as an adult (after age 18).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial is testing whether a form of vitamin B3 (called NAD) can help prevent or slow down Alzheimer's disease in people with Down syndrome. The goal is to see if this supplement can protect brain cells and improve memory or thinking.
This trial uses detailed brain tests to better match people with epilepsy to the right treatment. It may help by using “precision medicine” methods to understand what in the brain is driving seizures.
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This study tests if an investigational drug called AEF0217 can help improve thinking and daily living skills in people with Down syndrome. It's for ages 16-32 who have a caregiver to support them throughout the trial.
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