Colchicine for insulin sensitivity in type 1 diabetes
Treatments studied
Part of Hormones & metabolism, Immune system & allergy clinical trials.
This trial tests whether a daily oral medication called colchicine can improve how your body responds to insulin. It is for people with type 1 diabetes who have ongoing low-level inflammation and are already using a continuous glucose monitor.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You've had type 1 diabetes for over 5 years.
- Your C-peptide is less than 200 pmol/L, meaning your body makes little to no insulin.
- You are between 18 and 80 years old.
- You use a continuous glucose monitor (CGM) and your long-term blood sugar (HbA1c) is between 42 and 75 mmol/mol.
- Your insulin routine has been stable for at least 3 months, and you are willing to avoid certain anti-inflammatory drugs and other medications during the study.
- You have a blood test showing low-level inflammation (hs-CRP of 2 mg/L or higher) and no major liver, kidney, or blood disorders.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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