Combined therapy for cancer spread to the brain or spinal cord lining
Part of Brain & nervous system, Cancer clinical trials.
This trial tests a combination of two cancer drugs given together (one into the spinal fluid, one through a vein) to treat leptomeningeal metastasis, which is cancer that has spread to the lining of the brain or spinal cord. The goal is to see if this combination can control the cancer and improve symptoms.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older and have a confirmed solid tumor (cancer that started in an organ, like breast or lung).
- You have leptomeningeal metastasis (cancer spread to the lining of the brain or spinal cord), either confirmed by fluid/biopsy or by symptoms and imaging.
- You have not had certain brain radiation or other intrathecal (into the spinal fluid) treatments in the last 4 weeks.
- Your heart function is okay (ejection fraction at least 50%) and your organs are working well enough.
- You do not have active lung disease like interstitial lung disease or pneumonia, and no serious infections or bleeding disorders.
- You are expected to live at least 6 more weeks.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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