Studying anisodamine for improving blood flow during septic shock
Part of Blood & lymphatic, Genetic & congenital, Heart & circulation, Infections clinical trials.
This study tests a medication called anisodamine to see if it can improve blood flow in tiny blood vessels under the tongue in people with septic shock. This might help their organs work better and make them recover faster.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 18 and 85 years old.
- You must have septic shock, which means a serious infection that dropped your blood pressure so low you need medicine to raise it.
- You must be on a breathing machine (ventilator) to help you breathe when you join the study.
- You must have a special monitor (called a PiCCO) that helps doctors watch your heart and fluids.
- You must have a small tube in your arm giving you a steady dose of norepinephrine (a medicine that keeps your blood pressure up).
- You must be able to understand and sign a consent form (or have someone legally able to do it for you).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether a medication called papaverine can improve blood flow in the tiny vessels under the tongue in people with septic shock, which may help their organs get more oxygen. It is for patients in the intensive care unit (ICU) who are already on strong blood pressure support and a ventilator.
This study tests whether adding a sedative called dexmedetomidine affects blood flow in tiny vessels under the tongue and overall circulation in patients with septic shock. It may help doctors choose better sedation to improve recovery.
This trial tests a medication called esmolol (a short-acting beta-blocker) to see if it can improve blood flow in tiny blood vessels (microcirculation) and help stabilize blood pressure in people with septic shock who have a fast heart rate. The goal is to see if slowing the heart rate can improve organ function and recovery.
This trial studies whether combining anisodamine (a medicine for certain gut/smooth-muscle effects) with a low-molecular-weight blood thinner helps treat sepsis. It may be aimed at improving outcomes compared with standard care, but eligibility depends on safety factors like bleeding risk and organ function.
This trial studies how blood flow and organ “perfusion” look in ICU patients who are struggling with infection and low blood pressure. It may help doctors better measure and manage shock by comparing hemodynamic readings during standard treatment.
This trial tests whether adding vasopressin (a hormone that narrows blood vessels) to usual care can improve recovery in patients with septic shock (a severe infection causing very low blood pressure). If you are already on a strong blood pressure medication, this study may help stabilize your condition.
Hear when a new Septic Shock trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.