New drug combo for untreated high-risk mantle cell lymphoma
Treatments studied
Part of Blood & lymphatic, Cancer, Immune system & allergy clinical trials.
This trial tests a combination of three drugs (orelabrutinib, lisaftoclax, and rituximab) for people with mantle cell lymphoma who have not had treatment before and have high-risk features. The goal is to see if this combination works better than standard treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have been diagnosed with mantle cell lymphoma and have not yet had any treatment.
- You must be at least 14 years old.
- Your lymphoma must be at stage II (and needing treatment) or stage III/IV.
- You need to have at least one tumor that can be measured on a scan.
- You must have at least one high-risk feature, like a high MIPI score, high Ki67, TP53 mutation, or certain cell types.
- Your blood cell counts and liver/kidney function must be within certain ranges.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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