Predicting complications in high-risk fever with low white blood cells
Part of Blood & lymphatic, Cancer, Infections clinical trials.
This trial studies whether proteins in your blood can predict complications when you have a fever and very low white blood cells after cancer treatment. It aims to help doctors choose the best antibiotics early on.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have a blood cancer and are receiving strong chemotherapy, a stem cell transplant from a donor, or CAR-T therapy.
- You have a fever (temperature at least 100.9°F once or 100.4°F for at least an hour) and very low white blood cells (less than 100 cells per cubic millimeter) that are expected to last a week or more.
- You are in the hospital or need to be admitted right away for the fever.
- You have not had a recent infection or been colonized with drug-resistant bacteria.
- You can give blood samples multiple times and come back for check-ups.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether an antibiotic called ceftazidime-avibactam (CAZ-AVI) can help patients with blood cancers who have a fever and very low infection-fighting white blood cells. It may be an option for people whose doctors plan to use this specific antibiotic to treat their fever.
This trial tests whether it is safe to stop antibiotics earlier than usual in patients with a low white blood cell count (neutropenia) who have had a fever but have been fever-free for 48 hours. The goal is to reduce unnecessary antibiotic use and its side effects.
This trial looks at whether adding a medicine called G-CSF (which helps the body make more white blood cells) to antibiotics is better than antibiotics alone for children with cancer who develop a fever and low blood cell counts after chemotherapy.
This trial studies whether advanced genetic testing (next-generation sequencing) can help doctors better understand and manage neutropenic sepsis—a serious infection risk when white blood cell counts are too low. You may be considered if you develop fever or sepsis quickly (within 24 hours) while your counts are low.
This trial tests whether it is safe to stop antibiotics earlier than usual in children with cancer who have a fever and very low white blood cell counts, if they are at low risk of serious infection. The goal is to reduce unnecessary antibiotic use and its side effects.
This study looks at how long antibiotics should be given to cancer patients with fever and very low white blood cell counts after finding a certain type of bacteria (Gram-negative) in their blood. The goal is to find the best treatment duration to help patients recover without complications.
Hear when a new Febrile Neutropenia trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.