Clin2
NCT06278896Possibly a fitNot yet recruiting

Stopping antibiotics early for fever after chemotherapy

Hematologic MalignancyFebrile NeutropeniaAntibiotic Stewardship

Part of Blood & lymphatic, Cancer clinical trials.

This trial tests whether it is safe to stop antibiotics earlier than usual in patients with a low white blood cell count (neutropenia) who have had a fever but have been fever-free for 48 hours. The goal is to reduce unnecessary antibiotic use and its side effects.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 3
Enrollment
260 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You are 18 years or older.
  • You have a low white blood cell count (neutropenia) that is expected to last more than 7 days.
  • You have received or will receive chemotherapy.
  • You are currently in the hospital at Mass General Brigham or Dana-Farber Cancer Institute.
  • You had a fever (temperature of 100.9°F or higher) during this hospital stay or as the reason for admission.
  • You have been without a fever for at least 48 hours.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07277387Recruiting
Predicting complications in high-risk fever with low white blood cells

This trial studies whether proteins in your blood can predict complications when you have a fever and very low white blood cells after cancer treatment. It aims to help doctors choose the best antibiotics early on.

Barcelona, Barcelona
NCT07204522Recruiting
Antibiotic therapy for fever with low white blood cells in blood cancer

This trial tests whether an antibiotic called ceftazidime-avibactam (CAZ-AVI) can help patients with blood cancers who have a fever and very low infection-fighting white blood cells. It may be an option for people whose doctors plan to use this specific antibiotic to treat their fever.

Taiyuan, Shanxi
NCT06988826Not yet recruiting· Phase 4
Comparing two treatments for fever and low blood counts during cancer care

This trial looks at whether adding a medicine called G-CSF (which helps the body make more white blood cells) to antibiotics is better than antibiotics alone for children with cancer who develop a fever and low blood cell counts after chemotherapy.

NCT07051525Recruiting
Early vs. late stopping of antibiotics for fever in blood cancer treatment

This trial compares stopping antibiotics early (after fever resolves) versus continuing them as usual in adults with blood cancers who develop fever during treatment. It aims to find the best timing to reduce unnecessary antibiotic use.

Melbourne, Victoria
NCT07590648Not yet recruiting· Phase 4
Stopping antibiotics early for fever and low white blood cells in children with cancer

This trial tests whether it is safe to stop antibiotics earlier than usual in children with cancer who have a fever and very low white blood cell counts, if they are at low risk of serious infection. The goal is to reduce unnecessary antibiotic use and its side effects.

Barcelona, Barcelona
NCT07372131Recruiting
Shorter antibiotics for high-risk fever with low white blood cells

This study looks at how long antibiotics should be given to cancer patients with fever and very low white blood cell counts after finding a certain type of bacteria (Gram-negative) in their blood. The goal is to find the best treatment duration to help patients recover without complications.

Rozzano, Milan

Hear when a new Hematologic Malignancy trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.