Stopping antibiotics early for fever and low white blood cells in children with cancer
Part of Blood & lymphatic, Cancer clinical trials.
This trial tests whether it is safe to stop antibiotics earlier than usual in children with cancer who have a fever and very low white blood cell counts, if they are at low risk of serious infection. The goal is to reduce unnecessary antibiotic use and its side effects.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your child is 18 years old or younger and is receiving treatment for certain types of cancer, such as leukemia, lymphoma, or a solid tumor, with a high-intensity chemotherapy regimen.
- Your child has had a fever (temperature of 100.4°F or higher) and their blood test shows a very low count of neutrophils (a type of white blood cell that fights infection).
- Your child has already started antibiotics for this fever episode.
- Early blood tests show low levels of inflammation, and your child's blood pressure is stable, which means they are at low risk of a serious bacterial infection.
- After about 2 to 3 days, your child has not grown any bacteria in their blood tests, has been fever-free for more than 48 hours, and is feeling well overall.
- Your child's white blood cell count is still very low when they are randomly assigned to one of the two treatment groups.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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