Targeted radiation for recurrent rectal cancer
Part of Cancer, Digestive system clinical trials.
This trial tests targeted radiation (SBRT) for people whose rectal cancer has come back in the pelvis and cannot be surgically removed. The goal is to see if this focused radiation can control the tumor with fewer side effects.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 75 years old.
- You have rectal cancer that came back in the same area (locally recurrent) and surgery cannot remove it completely (unresectable).
- You either had no radiation to the pelvis before, or if you did, the dose was low (less than 50.4 Gy) and it ended more than 6 months ago without serious side effects.
- The cancer has not spread far away (no metastases), or if there are a few small spots they can be treated or removed.
- You are in good physical health (able to do daily activities) and your blood counts and liver/kidney function are within safe ranges.
- You are willing to use birth control during the study and for 6 months after treatment (if you or your partner could become pregnant).
- You do not have other active cancers, serious infections, heart or lung problems, or unstable medical conditions.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial studies a combination of SBRT (a precise kind of radiation) and an immunotherapy drug (PD-1 antibody) for people whose rectal cancer has come back in the pelvis and cannot be removed by surgery. The goal is to see if this treatment can shrink the tumor or stop it from growing.
This trial tests combining standard chemoradiation with an immunotherapy drug (toripalimab) before surgery for rectal cancer that has come back in the pelvis. The goal is to see if this approach can help remove the tumor more effectively.
This trial tests whether giving radiation (with or without chemo) before surgery can help people whose rectal cancer has come back in the pelvis. It aims to make the tumor removable and improve outcomes.
This trial tests giving a higher dose of radiation to people whose rectal cancer has come back in the pelvis after surgery and cannot be removed. It aims to see if more radiation can help control the tumor when surgery is not an option.
This Phase 2 trial tests whether giving targeted radiation and an immunotherapy drug together can control locally recurring rectal cancer in the pelvis. It may help shrink tumors and slow disease growth, especially after certain prior treatments.
This study tests a focused radiation treatment (SBRT) to a small, clearly identified spot in the prostate for men whose prostate cancer has come back after prior external beam radiation. It may help control cancer while limiting radiation to the rest of the prostate and nearby organs.
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