STEP-UP: Higher radiation for recurrent rectal cancer
Part of Cancer, Digestive system clinical trials.
This trial tests giving a higher dose of radiation to people whose rectal cancer has come back in the pelvis after surgery and cannot be removed. It aims to see if more radiation can help control the tumor when surgery is not an option.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- Your rectal cancer has returned in the pelvis after you had surgery for it, and doctors agree it cannot be fully removed (or you have chosen not to have surgery).
- You have no cancer spread that needs urgent drug treatment, or only a few small spots of spread that do not need treatment right away.
- You can carry out daily activities with little or no help (WHO performance score 0-2).
- You have not had radiation therapy in the last 6 months.
- You have not received certain targeted drugs (bevacizumab, panitumumab, or cetuximab) within 6 weeks before starting radiation.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a new combination of radiation, chemotherapy (NALIRIF), and an immunotherapy drug (PD-1 antibody) for rectal cancer that has come back in the pelvis. The goal is to see if this approach can help control the cancer better.
This trial tests whether a shorter, higher-dose radiation course (hypofractionated) combined with immunotherapy works better than standard radiation for locally recurrent rectal cancer that hasn't spread elsewhere. It's for people who haven't had chemotherapy or recent pelvic radiation.
This study looks at giving radiation and/or chemotherapy before surgery for rectal cancer that has come back in the pelvis. The goal is to see if this approach can shrink the tumor and make it easier to remove, potentially improving outcomes.
This trial tests an “induction chemotherapy” treatment before surgery for people whose rectal cancer has come back in the local area. The goal is to shrink/control the cancer early and improve outcomes after treatment.
This study tests whether giving a higher dose of radiation to rectal cancer tumors can help patients avoid surgery altogether. The goal is to shrink the tumor enough that surgery is no longer needed, preserving normal bowel function.
This trial studies a special type of radiation therapy for older adults with rectal cancer who are not able or willing to have surgery. It combines external beam radiation with a short, focused radiation treatment inside the rectum (brachytherapy) to try to control the cancer while avoiding the risks of surgery.
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