MDMA for severe chronic nerve pain
Treatments studied
Part of Brain & nervous system, Pain clinical trials.
This trial tests if MDMA, combined with psychotherapy, can help people with severe chronic nerve pain that hasn't improved with standard treatments. You'll receive either MDMA or a placebo to see if it safely reduces pain and improves your quality of life.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have had nerve pain for more than 3 months, confirmed by a pain specialist.
- Your pain is moderate to severe, with a PROMIS pain interference score of 60 or higher and average pain at least 5 out of 10.
- You have tried at least 2 recommended nerve pain medications without meaningful improvement.
- You are willing to use effective birth control if you could become pregnant, and you have sufficient English for therapy sessions.
- You are not currently taking certain antidepressants, stimulants, or other medications that could interact with MDMA.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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