Treatment
Methylphenidate clinical trials
We’re tracking 32 recruiting studies that include Methylphenidate, each written for real people, not researchers, below.
Recruiting studies
- NCT06073470Recruiting
Brain activity tests to predict ADHD medication response
This study looks at how the brain's electrical activity may predict whether a child with ADHD will respond well to methylphenidate (Ritalin). It aims to find biological markers that could help doctors choose the right treatment sooner.
TaipeiAges 6–18 - NCT06905587RecruitingPhase 3
Methylphenidate for fatigue in young brain tumor survivors
This trial tests whether the medicine methylphenidate (often used for ADHD) can help reduce severe fatigue in children and teens who have finished treatment for a brain tumor. If you're a young brain tumor survivor struggling with ongoing tiredness, this study may offer a new option.
AalborgAges 6–27 - NCT05776056RecruitingPhase 4
Methylphenidate for PTSD with memory and thinking problems
This study tests whether methylphenidate, a medication commonly used for attention issues, can help veterans with PTSD who also have memory or concentration problems. The goal is to see if it improves these cognitive symptoms.
Birmingham, AlabamaAges 18–65 - NCT05133804RecruitingPhase 2
Testing two medications for PTSD attention and emotions
This Phase 2 study tests whether reboxetine or methylphenidate can improve attention and emotional or sensory problems in adults with post-traumatic stress disorder (PTSD). You may be eligible if you have a confirmed PTSD diagnosis and are able to meet medication and safety requirements.
AfulaAges 20–60 - NCT06465641RecruitingPhase 4
Methylphenidate for ADHD symptoms in KBG syndrome
This study tests if the medication methylphenidate (commonly used for ADHD) can help manage attention and behavior problems in people with KBG syndrome. Each person acts as their own test case to see if the drug works for them.
Nijmegen, GelderlandAges 6–20 - NCT04781972RecruitingPhase 4
Brain scan study of ADHD effects from methylphenidate
This study uses brain imaging (MRI) to see how methylphenidate affects brain activity in people with ADHD. It may help doctors better understand how this medicine works and who benefits most.
Baltimore, MarylandAges 6–40 - NCT02951754RecruitingPhase 4
Methylphenidate for adults with ADHD
This trial tests whether methylphenidate (a stimulant medicine) helps adults with attention-deficit/hyperactivity disorder (ADHD). It is checking safety and effectiveness for people who can take the immediate-release form of the medicine.
Porto Alegre, Rio Grande do SulAges 18 years+ - NCT03781752RecruitingPhase 4
Test of methylphenidate effects based on a genetic difference
This trial studies whether a genetic difference called “carboxylesterase 1” changes how methylphenidate (a common ADHD medicine) works for children with ADHD. It’s a single-dose test, meant to help understand why some children respond differently to ADHD medication.
Gainesville, FloridaAges 6–17 - NCT04419272RecruitingPhase 4
Methylphenidate for thinking problems in adults with focal seizures
This trial studies whether methylphenidate (a stimulant medicine) can improve thinking and memory problems related to epilepsy. You may be kept on your usual seizure medicines, and your thinking will be tested over about 16 weeks.
Miami, FloridaAges 18 years+ - NCT05832489RecruitingPhase 3
EEG-MRI test of methylphenidate in adult attention symptoms
This Phase 3 study tests how methylphenidate affects brain signals and attention in adults with ADHD, and in adults with mood-related attention problems. It also includes healthy volunteers to compare brain responses during brain scanning.
StrasbourgAges 18–60 - NCT05957055RecruitingPhase 2
ADHD medicine compared for kids with type 1 diabetes
This Phase 2 study compares two ADHD medicines—lisdexamfetamine and methylphenidate—in children who have ADHD and type 1 diabetes. It’s designed to see which option works better and is safe/effective for managing ADHD without causing major problems for diabetes care.
Lodz, Łódź VoivodeshipAges 8 years–16.5 years - NCT06577779RecruitingPhase 4
Testing Jornay PM for adult ADHD symptoms into the evening
This study tests if Jornay PM, a long-acting ADHD medication, helps control symptoms, focus, and emotions throughout the day and into the early evening in adults with ADHD. It is an open-label study, meaning everyone knows they are getting the medication, and then they are randomly assigned to different observation groups.
New York, New YorkAges 18–60 - NCT07226219RecruitingPhase 1
Methylphenidate for Attention in Sickle Cell Disease
This trial tests if a medication called methylphenidate can help children with sickle cell disease who have trouble with attention, focus, or executive function. It aims to see if it can improve daily life and school performance.
Memphis, TennesseeAges 8–17 - NCT07279740RecruitingPhase 2
Brain stimulation plus medication for apathy in dementia
This study tests if combining a type of brain stimulation (repetitive TMS) with a medication (methylphenidate, commonly used for ADHD) can improve apathy in people with dementia. If you have Alzheimer's or mixed dementia and struggle with low motivation, this trial may help you.
Toronto, OntarioAges Any age - NCT07771530RecruitingPhase 2
Medication or dog therapy for PTSD symptoms
This study tests whether a combination of two medications (reboxetine and Ritalin) is more effective than dog-assisted therapy for reducing PTSD symptoms. Participation involves either taking the medications or attending dog therapy sessions.
HaifaAges 18–70 - NCT03511118Recruiting
Drug safety study for breastfeeding mothers and babies
This study measures how common medicines move through a breastfeeding parent’s milk and checks safety in both the parent and breastfed baby. It may help doctors use these medicines more safely while you continue breastfeeding.
La Jolla, CaliforniaAges Any age - NCT05880342RecruitingPhase 3
Study how the brain affects fatigue after exercise
This trial studies how your brain responds when you feel mentally and physically tired, using trained healthy volunteers. It may help researchers understand fatigue better, which could guide future treatments for people who struggle with fatigue.
Brussels, Brussels CapitalAges 18–35 - NCT04421248RecruitingPhase 4
Testing blood or brain markers in kids with ADHD
This Phase 4 study checks whether certain markers change in the brain/body when children with ADHD take methylphenidate (a stimulant). It also compares these markers with healthy children to better understand ADHD.
Baltimore, MarylandAges 8–12 - NCT06906328Recruiting
ADHD and addiction: can cognitive training help?
This study tests whether adding a cognitive remediation program to methylphenidate (a medication for ADHD) improves treatment response in adults who have both ADHD and a substance use or behavioral addiction. It aims to help patients manage symptoms better over the short and medium term.
Brest, Brittany RegionAges 18–99 - NCT07301632RecruitingPhase 2
MDMA for severe chronic nerve pain
This trial tests if MDMA, combined with psychotherapy, can help people with severe chronic nerve pain that hasn't improved with standard treatments. You'll receive either MDMA or a placebo to see if it safely reduces pain and improves your quality of life.
Toronto, OntarioAges 18 years+ - NCT06355414RecruitingPhase 1
Psilocybin for chronic back pain and depression
This trial tests if psilocybin, a psychedelic drug, can help people with long-term low back pain who also have depression. If you qualify, you'll receive psilocybin in a controlled setting, and researchers will see how it affects your pain and mood.
Baltimore, MarylandAges 21–80 - NCT07594652RecruitingPhase 4
ADHD Treatment for Children With Epilepsy
This study tests whether a specific ADHD medication (Jornay PM) is safe and helpful for children who have both epilepsy and ADHD. Researchers want to see if treating ADHD can improve focus and behavior without making seizures worse.
Baltimore, MarylandAges 6–17 - NCT03781765RecruitingPhase 4
Testing stimulant vs non-stimulant ADHD treatments in young kids
This study compares stimulant and non-stimulant ADHD medicines in kids who have not taken ADHD medication before. It also studies how these treatments affect brain “reward” processes, which may be linked to substance-use risk.
New York, New YorkAges 7–12 - NCT05630781Recruiting
Orexin's role in the neurobiology of addiction
This study looks at how a brain chemical called orexin affects addiction. Researchers will give a medication that blocks orexin to see if it helps reduce cravings or use. It might help people who smoke or vape regularly.
Baltimore, MarylandAges 18–60
What Methylphenidate is being studied for
Conditions with recruiting Methylphenidate studies.
Common questions
- Are there clinical trials studying Methylphenidate?
- Yes. Clin2 currently lists 32 recruiting studies that include Methylphenidate, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Methylphenidate trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Methylphenidate an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Methylphenidate or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.