Melatonin and metformin for PCOS with insulin resistance
Part of Hormones & metabolism, Women’s health & pregnancy clinical trials.
This study tests if adding melatonin to metformin can improve insulin resistance and other health markers in women with PCOS who have insulin resistance. It compares the combination to metformin alone.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with PCOS (polycystic ovary syndrome) using the Rotterdam criteria.
- You are a woman between 18 and 35 years old.
- You have insulin resistance, confirmed by a blood test (HOMA-IR score over 2.6).
- Your BMI is between 18.5 and 30 (not underweight and not obese).
- You do not have uncontrolled diabetes, thyroid problems, or high prolactin levels.
- You have not taken metformin or similar insulin-sensitizing medicines in the last three months.
- You do not have serious kidney, liver, or heart disease.
- You are not allergic to melatonin.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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