Clin2
NCT07318610Possibly a fitRecruiting

Study of a new blood thinner in people with leg artery disease

Peripheral Artery Disease (PAD)

Treatments studied

Part of Heart & circulation clinical trials.

This trial tests if a new blood-thinning drug (factor XI inhibitor) can prevent serious heart and leg problems in people who recently had a leg artery procedure. It compares the new drug to standard care for up to 3 years.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 3
Enrollment
7,050 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You have had a procedure (like angioplasty, stenting, or bypass) to open a blocked leg artery within the last 10 days
  • You have at least one of these risk factors: a synthetic bypass graft, a long blockage, a prior leg procedure or amputation, diabetes, heart disease, kidney disease, or being 75 or older
  • You are not currently taking a blood thinner for a condition like a blood clot or irregular heartbeat
  • You do not have a history of a serious bleeding problem or brain bleed
  • You are not allergic to the study medications

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07175428Recruiting· Phase 2
Safety of a New Blood Thinner in AFib Patients

This study tests the safety of a new blood thinner for people with atrial fibrillation (AFib) who need long-term stroke prevention. If you qualify, the study will compare this medication to standard anticoagulation therapy.

Dothan, Alabama
NCT07430956Recruiting· Phase 3
Stroke prevention in atrial fibrillation without standard blood thinners

This trial tests a new medication to prevent strokes and blood clots in people with atrial fibrillation (an irregular heartbeat) who cannot safely take standard blood thinners. The drug works by blocking a different clotting factor, which may lower bleeding risks.

Dothan, Alabama
NCT06873321Recruiting· Phase 4
Blood thinners after leg artery surgery to prevent clots

This trial compares two blood-thinning strategies after leg artery surgery or angioplasty to prevent dangerous blood clots. Participants will receive either rivaroxaban plus aspirin or aspirin alone, and researchers will monitor for clots over 30 days.

Pernambuco, Pernambuco
NCT06850207Not yet recruiting
Blood thinners after leg artery treatment

This study looks at whether giving certain blood-thinning medicines after a leg artery procedure helps prevent serious problems like heart attacks or strokes. It compares different treatment plans to see which is safer and more effective.

NCT07832578Recruiting· Early Phase 1
Aspirin with or without rivaroxaban for severe leg artery disease

This trial compares two ways to prevent blood clots in people with severe leg blockage (chronic limb-threatening ischemia) who are not having surgery. It tests aspirin alone versus a newer blood thinner (rivaroxaban) plus aspirin, to see which works better in preventing complications.

Lahore, Punjab Province
NCT07015905Recruiting· Phase 3
Study of REGN7508 vs. standard blood thinners after knee replacement

This trial compares a new blood thinner called REGN7508 to two standard blood thinners (apixaban and enoxaparin) to prevent blood clots after total knee replacement surgery. The goal is to see which is safer and more effective.

Sheffield, Alabama

Hear when a new Peripheral Artery Disease (PAD) trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.