Aspirin with or without rivaroxaban for severe leg artery disease
Treatments studied
Part of Heart & circulation clinical trials.
This trial compares two ways to prevent blood clots in people with severe leg blockage (chronic limb-threatening ischemia) who are not having surgery. It tests aspirin alone versus a newer blood thinner (rivaroxaban) plus aspirin, to see which works better in preventing complications.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 40 to 70 years old and have type 2 diabetes with an HbA1c above 8% (average blood sugar over 3 months).
- You have chronic limb-threatening ischemia (a severe blockage in your leg causing pain or wounds) and are being treated without surgery or stents.
- Your blood pressure is above 130/90 but below 180/100, and your total cholesterol is at least 200 mg/dL.
- You can walk less than 100 meters (about one football field) before leg pain stops you, and your ankle-brachial index is below 0.6 (a measure of blood flow).
- You have not had a previous amputation, leg ulcer cleaning, varicose vein surgery, active bleeding, recent major surgery (within a month), or kidney failure needing dialysis.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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