Comparing two injected medicines for lymphatic malformations in children
Treatments studied
Part of Blood & lymphatic, Genetic & congenital clinical trials.
This study compares two injected medicines, bleomycin and doxycycline, to see which works better for shrinking lymphatic malformations (abnormal fluid-filled cysts) in children. If your child qualifies, they would receive one of these treatments to help reduce the size of the cysts.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Child is between 0 and 12 years old.
- The lymphatic malformation is the macrocystic (large cysts) or mixed type, confirmed by imaging.
- No prior sclerotherapy or surgery for the malformation.
- Parents or guardians must give informed consent.
- No allergy to bleomycin or doxycycline, no significant other medical conditions, and no active infection at the lesion site.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a medicine called bleomycin, injected into lymphatic malformations (abnormal fluid-filled growths) to shrink them. It is for children under 14 whose malformations are growing quickly, causing symptoms or problems, and cannot be removed by surgery alone.
This study tests a treatment called bleomycin electrosclerotherapy (BEST) for people with low-flow vascular malformations—abnormal clusters of blood or lymph vessels that can cause pain or swelling. The treatment combines a drug (bleomycin) with a small electrical current to shrink these abnormal vessels, and the goal is to see if it helps when other treatments haven't worked well or the problem came back.
This Phase 2 trial tests whether an injected medicine called TARA-002 placed inside lymphatic cysts can safely shrink lymphatic malformations in children. It may help especially when the cysts are mainly in the head, neck, or chest area.
This trial tests different doses of sirolimus (a medication that slows cell growth) to find the best dose for treating cystic lymphatic malformations in children. It may help shrink the abnormal fluid-filled growths and improve symptoms.
This study is testing a treatment called electrosclerotherapy for low-flow venous malformations. It uses a medicine (bleomycin) injected into the abnormal blood vessels to shrink them. The goal is to see how well it works and how safe it is.
This trial tests whether injecting a medicine called bleomycin is better than a standard treatment for reducing keloids. It compares two common treatments to see which works best for patients like you.
Hear when a new Lymphatic Abnormality trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.