Steroids to prevent side effects after aortic repair
Treatments studied
Part of Heart & circulation clinical trials.
This trial tests whether giving steroids before a planned aortic repair can prevent a complication called postimplantation syndrome, which causes fever and inflammation. It might help people having elective surgery for a type B aortic dissection or thoracoabdominal aortic aneurysm.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are scheduled for elective (non-emergency) surgery on the aorta in your chest or abdomen
- You can give your own informed consent
- You are expected to be available for long-term follow-up appointments
- You do not have severe kidney or liver problems, uncontrolled diabetes, active infections, or autoimmune disease
- You have no history of stomach ulcers, genetic connective tissue disease, or prior aortic stent procedure
- You are not pregnant, and have not used steroids, chemotherapy or immunosuppressants in the last 3 months
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether giving a steroid medication shortly after a TAVR procedure can reduce the chance of developing a heart-rhythm problem called left bundle branch block. This could help your heart beat normally and avoid needing a pacemaker later.
This trial is testing whether a single dose of the steroid methylprednisolone, given before heart surgery, can protect your kidneys from damage during the operation. If you qualify, you'll receive the drug or a placebo, and your kidney function will be monitored closely.
This study tests whether an “add-on” anti-inflammatory approach can help after surgery for certain problems affecting the aorta (the body’s main artery) soon after symptoms begin. It may be designed to reduce inflammation-related complications in people who are treated quickly and can join follow-up.
This trial tests whether taking aspirin after a specific type of aortic surgery can help prevent strokes. If you've had a total endovascular aortic arch repair with branch vessel reconstruction, you may be able to join.
This trial tests whether taking a cholesterol-lowering medicine (a statin) after certain aortic surgeries can reduce harmful changes in the heart and other organs. You might benefit by lowering the risk of ongoing damage after your acute aortic condition and surgery.
This trial tests if dexmedetomidine or methylprednisolone is better at reducing inflammation during coronary artery bypass grafting (CABG) with a heart-lung machine. The goal is to find a treatment that helps patients recover better.
Hear when a new Myocardial Injury trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.