Stem cell transplant with lower-intensity chemo for severe aplastic anemia
Treatments studied
Part of Blood & lymphatic clinical trials.
This Phase 1 trial tests a “lower-intensity” chemotherapy plan followed by a stem cell transplant from a related half-match donor for severe aplastic anemia that has returned or did not respond to prior medicines. It aims to see if this approach is safe and works well enough to help your blood counts recover.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 40 and 75 years old when you join
- You have severe aplastic anemia that did not improve (or came back) after at least one immune-suppressing treatment
- You do not have a fully matched sibling donor, but you do have a related half-match donor who can donate bone marrow
- You are well enough for transplant, with heart, lung, kidney, and liver tests within required limits
- You and (if applicable) your donor can sign consent, and you must be able to follow the study plan
- You test negative for certain infections like HIV and active hepatitis, and you must not have had a prior stem cell transplant
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a “half-matched” stem cell transplant for children and teens with severe aplastic anemia when a fully matched donor isn’t available. It may help rebuild blood-making cells after prior treatments did not work well enough.
This trial tests whether an early bone marrow transplant from a half-matched family member or an unrelated donor can help people with severe aplastic anemia. It aims to restore the body's ability to make healthy blood cells.
This study is testing whether a stem cell transplant (from a matched relative, unrelated donor, or half-matched donor) can help adults aged 40–60 with severe aplastic anemia that didn't get better or came back after standard treatments.
This trial compares two first treatments for severe aplastic anemia: a half-matched (haploidentical) stem cell transplant versus immune-suppressing medicine. It is for people aged 14–70 who do not have a fully matched sibling donor.
This Phase 2 study tests a bone marrow transplant from a closely matched related donor, plus medicine after the transplant to help prevent immune complications. It may be an option if you have severe aplastic anemia and meet specific health and lab requirements.
This trial tests a stem cell transplant option for children or young adults with severe aplastic anemia that did not respond to prior immune-suppressing treatment. It uses a “half-matched” donor and gives post-transplant cyclophosphamide to help the donor cells work and reduce certain immune reactions.
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