Haploidentical transplant for severe aplastic anemia in children
Treatments studied
Part of Blood & lymphatic clinical trials.
This trial tests a “half-matched” stem cell transplant for children and teens with severe aplastic anemia when a fully matched donor isn’t available. It may help rebuild blood-making cells after prior treatments did not work well enough.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be age 21 or younger when you enroll
- Have severe aplastic anemia or a single blood cell type that’s very low, based on blood tests and bone marrow findings
- No well-matched sibling or fully matched unrelated donor available in time
- Have either failed immune-suppressing treatment or your disease returned after stopping it (unless your case is extremely unlikely to respond)
- Have a family donor who is half-matched (at least 3 of 6 genetic matches)
- Meet heart, kidney, lung, liver health, and general activity strength requirements
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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Other trials that look related to this one.
This study is testing whether a stem cell transplant (from a matched relative, unrelated donor, or half-matched donor) can help adults aged 40–60 with severe aplastic anemia that didn't get better or came back after standard treatments.
This trial tests a special type of donor stem cell transplant (with donor T-cells removed) to treat serious non-cancer blood problems in children. It may help by resetting the bone marrow so the body can make healthy blood cells again.
This trial tests a stem cell transplant option for children or young adults with severe aplastic anemia that did not respond to prior immune-suppressing treatment. It uses a “half-matched” donor and gives post-transplant cyclophosphamide to help the donor cells work and reduce certain immune reactions.
This trial tests whether an early bone marrow transplant from a half-matched family member or an unrelated donor can help people with severe aplastic anemia. It aims to restore the body's ability to make healthy blood cells.
This Phase 1 trial tests a “lower-intensity” chemotherapy plan followed by a stem cell transplant from a related half-match donor for severe aplastic anemia that has returned or did not respond to prior medicines. It aims to see if this approach is safe and works well enough to help your blood counts recover.
This trial tests whether giving children with aplastic anemia a transplant using a matched unrelated donor (a bone marrow donor who is not a family member) can help treat their condition. It aims to see if this approach is effective and safe for children who qualify.
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