Migraine with aura and PFO study

This study tests whether a substance called PACAP38 can safely bring on migraine attacks with aura in a controlled setting. It may help us understand what causes migraine with aura and develop better treatments.

This study tests whether a substance called CGRP (a protein linked to migraines) can safely trigger a migraine with aura in people who already have this condition. You'll receive an infusion and be monitored to see how your body responds.

This study is testing a device that closes a small opening in the heart (PFO) to see if it reduces migraines in people who have migraines with aura and haven't gotten relief from other treatments.

This study is for people who have migraines and a small hole in their heart called a patent foramen ovale (PFO). It will track your health over time to learn more about how these conditions are related.

This trial tests if closing a common heart defect (PFO) can improve migraine symptoms and brain function. It compares people with migraine who get the closure procedure to those without migraine.

This study looks at the detailed flow pattern through a patent foramen ovale (PFO)—a small opening in the heart—and how it may relate to stroke, TIA, or migraine. Doctors use special ultrasound testing with contrast to better understand who is most affected.