Comparing carvedilol and propranolol to prevent variceal rebleeding
Treatments studied
Part of Digestive system clinical trials.
This trial tests whether carvedilol or propranolol works better to prevent another bleeding episode from enlarged veins in the stomach or esophagus (varices) after they have been treated with endoscopy. If you have cirrhosis and had a variceal bleed 6 to 30 days ago, this study may help find the most effective medicine for you.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have cirrhosis (scarring of the liver) and have had bleeding from enlarged veins in your stomach or esophagus.
- Your most recent bleeding episode was between 6 and 30 days ago.
- You are between 18 and 75 years old.
- You are willing to take either carvedilol or propranolol and attend all follow-up visits.
- You do not have conditions that prevent use of these medicines, like asthma or severe heart failure.
- You have not had certain previous surgeries or treatments for variceal bleeding.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study tests whether adding a second drug (midodrine) to the standard drug (carvedilol) is better at preventing another bleeding episode from varices in people with cirrhosis. It aims to reduce the risk of early re-bleeding and improve outcomes.
This trial tests whether adding endoscopic banding helps prevent bleeding from enlarged varices in people with cirrhosis who still have high-risk varices despite taking carvedilol.
This trial compares two treatments (banding or a medication called carvedilol) to prevent the first episode of bleeding from enlarged veins in the esophagus in people with liver cancer. The goal is to find which approach is safer and more effective.
This study compares two ways to prevent bleeding from enlarged veins in the esophagus (varices) in people with liver cancer and cirrhosis. One method uses a medication called carvedilol alone, while the other combines carvedilol with a procedure called band ligation, which ties off the veins to prevent bleeding.
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